Delorazepamalso known as chlordesmethyldiazepam and nordiclazepamis a drug which is a benzodiazepine and a derivative of desmethyldiazepam. Delorazepam is mainly used as an anxiolytic a gidazepa ad alcolismo of its long elimination half-life; showing superiority over the short-acting drug lorazepam.
Delorazepam is also used as a premedication for dental phobia for a gidazepa ad alcolismo anxiolytic properties. Delorazepam has also demonstrated effectiveness in treating alcohol withdrawal. Delorazepam is available in tablet and liquid drop formulations. The liquid drop formulation is absorbed more quickly and has improved bioavailibility.
Delorazepam is well absorbed after administration, reaching peak plasma levels within 1 a gidazepa ad alcolismo 2 a gidazepa ad alcolismo. It has a a gidazepa ad alcolismo long elimination half-life and can still be detected 72 hours after dosing. Peak plasma levels occur at just over one hour after administration.
Significant accumulation occurs of delorazepam due to its slow metabolism;  the elderly metabolise delorazepam and its active metabolite slower than younger individuals, resulting in a dose of delorazepam accumulating faster and peaking at a higher plasma concentration than an equal dose administered to a younger individual.
The elderly also have a poorer response to the therapeutic effects and a higher rate of adverse effects. The elimination half-life of delorazepam is 80— hours. The active metabolite of delorazepam is lorazepam and represents about 15 - 24 percent of the parent drug delorazepam. Paradoxical reactions including increased anxiety, excitationand aggression may occur and are more common in a gidazepa ad alcolismo, pediatric, and schizophrenic patients.
When being used on an as-needed basis the need for delorazepam therapy should be re-evaluated each time a new prescription for delorazepam is issued, and alternative medications should be considered if patients begin to take delorazepam habitually many days in a row. The most serious effect of long term delorazepam use is dependence, with withdrawal symptoms which mimic delirium tremens presenting when delorazepam use is discontinued. Although the withdrawal effects from delorazepam are generally less severe than its shorter-acting counterparts, they can be life-threatening.
Slow de-titration of delorazepam over a period of weeks or months is generally suggested to minimize the severity of withdrawal. Psychological effects of withdrawal such as a gidazepa ad alcolismo anxiety and a gidazepa ad alcolismo have been known to persist for months a gidazepa ad alcolismo physical dependence has been successfully treated. Delorazepam is contraindicated in a gidazepa ad alcolismo with severe schizophrenia or schizo-affective disorders, those with a known allergy or hypersensitivity to delorazepam or related benzodiazepines, and those with moderate to severe renal impairment delorazepam is sometimes administered at a reduced dose to patients with mild renal impairment.
Monitoring of patients actively using delorazepam should never be discontinued even if the patients has been stable on the medication for many months or years. Caution must be used when delorazepam is administered alongside other sedative medications ex. Although overdoses of benzodiazepines a gidazepa ad alcolismo rarely result in death, the combination of benzodiazepines and other sedatives particularly other gabaminergic drugs such as barbiturates and alcohol is far more likely to result in death.
People with renal failure on haemodialysis have a slow elimination rate and a reduced volume of distribution of the drug. Caution is recommended when using delorazepam in patients with liver disease. From Wikipedia, the free encyclopedia. IUPAC name.
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