Amobarbital formerly known as amylobarbitone or sodium amytal is cura di delirium tremens a fenazepa drug that is a barbiturate derivative. It has sedative - hypnotic properties. It is a white crystalline powder with no odor and a slightly bitter taste. It was first synthesized in Germany in It is considered an intermediate acting barbiturate.
If amobarbital is taken for cura di delirium tremens a fenazepa periods of time, physical and psychological dependence can develop. Amobarbital withdrawal mimics delirium tremens and may be life-threatening. It was widely abused, known as "blue heavens" on the streets, and was discontinued by Eli Lilly in the early s.
In an in vitro study in fat thalamic slices amobarbital worked by activating GABA A receptorswhich decreased input resistance, depressed burst and tonic firingespecially in ventrobasal and intralaminar neuronswhile at the same time increasing burst duration and mean conductance at individual chloride channels ; this increased both the amplitude and decay time of inhibitory cura di delirium tremens a fenazepa currents.
Amobarbital has been used in a study to inhibit mitochondrial electron transport in the rat heart in an attempt to preserve mitochondrial function following reperfusion. A study found that amobarbital increases benzodiazepine receptor binding in vivo with less potency than secobarbital and pentobarbital in descending orderbut greater than phenobarbital and barbital in descending order.
Amobarbital undergoes both hydroxylation to form 3'-hydroxyamobarbital,  and N-glucosidation  to form 1- beta-D-glucopyranosyl amobarbital. When given slowly by an intravenous route, sodium amobarbital has a reputation for acting as a so-called truth serum. Under the influence, a person will divulge information that under normal circumstances they would block.
This was most likely due to loss of inhibition. As such, the drug was first employed clinically by Dr. William Bleckwenn at the University of Wisconsin to circumvent inhibitions in psychiatric patients. The drug may be used intravenously to interview patients with catatonic mutismsometimes combined with caffeine to prevent sleep.
It was used by the United States armed forces during World War II in an attempt to treat shell shock and return soldiers to the front-line duties. It was discontinued in the early 80's largely replaced by the benzodiazepine family of drugs. Amobarbital was also widely abused, known on the streets as "blue heavens" because of their blue capsule.
Amobarbital has been known to decrease the effects of hormonal birth control, sometimes to the point of uselessness. Some side effects of overdose include confusion severe ; decrease in or loss of reflexes; drowsiness severe ; fever; irritability continuing ; low body temperature; poor judgment; shortness of breath or slow or troubled breathing; slow heartbeat; slurred speech; staggering; trouble in sleeping; unusual movements of the eyes; weakness severe.
Amobarbital 5-ethylisoamylbarbituric acidlike all barbiturates, is synthesized by reacting malonic acid derivatives with urea derivatives. It has been used to convict alleged murderers such as Andres English-Howardwho strangled his girlfriend to death but claimed innocence.
He was surreptitiously administered the drug by his lawyer, and under the influence of it he revealed why he strangled her and under what circumstances. On the night of August 28,the housekeeper of actor Robert Walker found him to be in an emotional state. She called Walker's psychiatrist who arrived and administered amobarbital for sedation. Walker was allegedly drinking prior to his emotional outburst, and it is believed the combination of amobarbital and alcohol resulted in a severe reaction.
As a result, he passed out and stopped breathing, and all efforts to resuscitate him failed. Walker died at 32 years old. Eli Lilly manufactured Amobarbital under the brand name Amytal, it was discontinued in the 's replaced largely by the benzodiazepine family of drugs.
Amytal was also widely abused. Street names for Amobarbital include "blues", "blue angels", "blue birds", "blue devils", and "blue heavens" due to their blue capsule. From Wikipedia, the free encyclopedia. IUPAC name. Interactive image. British Journal of Pharmacology. Translational Research. The Journal of Pharmacology and Experimental Therapeutics. Research Communications in Chemical Pathology and Cura di delirium tremens a fenazepa. Journal of Chromatography. Wisconsin Medical Journal.
Social Work. Battle of the Bulge - program transcript. Archived from the original on Retrieved Ben Kimmelman, Captain, 28th Infantry: The assumptions cura di delirium tremens a fenazepa that this would have some kind of cathartic effect, the sodium amytal, which the men called blue 88's. You know, the most effective artillery piece of the Germans was the 88 and this was blue 88sbecause the sodium amytal was a blue tablet.
CBS News. Archived from the original on April 5, Retrieved Cura di delirium tremens a fenazepa 4, GABA A receptor positive modulators. Etomidate Metomidate Propoxate. Fospropofol Propofol Cura di delirium tremens a fenazepa. Glutethimide Methyprylon Piperidione Pyrithyldione. Glutethimide Methyprylon Pyrithyldione Piperidione. Serotonin antagonists and reuptake inhibitors Etoperidone Nefazodone Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramineetc.
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